1 00:00:05,190 --> 00:00:02,550 so joining me now here in mission 2 00:00:06,789 --> 00:00:05,200 control houston dr hans christian gunga 3 00:00:09,030 --> 00:00:06,799 he's one of the principal investigators 4 00:00:10,870 --> 00:00:09,040 for the circadian rhythm study uh it's 5 00:00:12,390 --> 00:00:10,880 taking place right now as we speak 6 00:00:14,070 --> 00:00:12,400 onboard the international space station 7 00:00:15,829 --> 00:00:14,080 japanese astronaut koichi wakata is 8 00:00:17,510 --> 00:00:15,839 engaged in it 9 00:00:19,189 --> 00:00:17,520 dr goonga thanks so much for being here 10 00:00:21,189 --> 00:00:19,199 today really appreciate it and first 11 00:00:22,950 --> 00:00:21,199 start me off real quick what is what is 12 00:00:24,390 --> 00:00:22,960 this circadian rhythm study why is you 13 00:00:26,150 --> 00:00:24,400 know why why are we doing it on board 14 00:00:28,870 --> 00:00:26,160 the international space station 15 00:00:32,150 --> 00:00:28,880 um actually this is a very important 16 00:00:34,229 --> 00:00:32,160 question because the the astronauts they 17 00:00:36,310 --> 00:00:34,239 they do not have a real 18 00:00:39,750 --> 00:00:36,320 day there they have several days and 19 00:00:41,750 --> 00:00:39,760 sunsets and such and so there there is 20 00:00:42,950 --> 00:00:41,760 over the millions of years we have 21 00:00:46,229 --> 00:00:42,960 developed 22 00:00:48,709 --> 00:00:46,239 the organism has adapted to this sunset 23 00:00:51,830 --> 00:00:48,719 and sundown so you have an internal 24 00:00:55,029 --> 00:00:51,840 rhythm and this internal rhythm is very 25 00:00:55,830 --> 00:00:55,039 important for your capabilities for your 26 00:00:57,990 --> 00:00:55,840 will 27 00:01:00,150 --> 00:00:58,000 vigor lens for all the things you are 28 00:01:03,349 --> 00:01:00,160 doing whether you sleep or not sleep 29 00:01:05,109 --> 00:01:03,359 and so if that rhythm is destroyed by 30 00:01:07,990 --> 00:01:05,119 having every day 31 00:01:10,390 --> 00:01:08,000 several times sunsets and sunlight 32 00:01:12,550 --> 00:01:10,400 sunsets some sunrise sun setting however 33 00:01:15,510 --> 00:01:12,560 yeah 34 00:01:16,310 --> 00:01:15,520 that's actually the case and that's why 35 00:01:20,230 --> 00:01:16,320 we 36 00:01:23,510 --> 00:01:20,240 introduced this study to uh analyze 37 00:01:25,190 --> 00:01:23,520 uh by measuring the core temperature 38 00:01:28,630 --> 00:01:25,200 that means the temperature in the body 39 00:01:31,830 --> 00:01:28,640 the temperature in the body is a signal 40 00:01:34,149 --> 00:01:31,840 for this circadian rhythm usually you 41 00:01:37,990 --> 00:01:34,159 usually have in the morning here on the 42 00:01:40,390 --> 00:01:38,000 ground between five and six am you have 43 00:01:41,789 --> 00:01:40,400 the lowest temperature that means in the 44 00:01:44,389 --> 00:01:41,799 in the body about 45 00:01:47,830 --> 00:01:44,399 36.5 and you have your highest 46 00:01:48,710 --> 00:01:47,840 temperature in the afternoon at 6 00 pm 47 00:01:51,030 --> 00:01:48,720 or so 48 00:01:53,350 --> 00:01:51,040 and this is about one day it sounds 49 00:01:54,630 --> 00:01:53,360 sounds less it's only one degree 50 00:01:56,789 --> 00:01:54,640 difference it's not a huge difference 51 00:01:59,590 --> 00:01:56,799 but no no it's measurable but it's 52 00:02:01,429 --> 00:01:59,600 measurable and it's it's a strong signal 53 00:02:04,550 --> 00:02:01,439 for the organism 54 00:02:05,990 --> 00:02:04,560 you you must realize that the the core 55 00:02:09,109 --> 00:02:06,000 temperatures is 56 00:02:10,949 --> 00:02:09,119 changing of metabolism and 57 00:02:12,150 --> 00:02:10,959 several other functions 58 00:02:14,790 --> 00:02:12,160 they 59 00:02:17,270 --> 00:02:14,800 are introduced by your internal rhythm 60 00:02:19,750 --> 00:02:17,280 which is coming from all the different 61 00:02:21,430 --> 00:02:19,760 or is organized from the different 62 00:02:23,750 --> 00:02:21,440 inputs and 63 00:02:26,710 --> 00:02:23,760 the core temperature is so to say the 64 00:02:28,790 --> 00:02:26,720 master of the orchestra of the different 65 00:02:31,990 --> 00:02:28,800 functions it's like an orchestra if you 66 00:02:35,190 --> 00:02:32,000 and you can expect if the the master of 67 00:02:38,949 --> 00:02:35,200 an orchestra is not ready 68 00:02:41,190 --> 00:02:38,959 and if it's uh uh working with different 69 00:02:44,309 --> 00:02:41,200 orchestras that is a real that's a mess 70 00:02:45,830 --> 00:02:44,319 can you i can mess you up okay well so 71 00:02:47,509 --> 00:02:45,840 and like i had mentioned koichi's 72 00:02:48,790 --> 00:02:47,519 participating in this right now on board 73 00:02:50,630 --> 00:02:48,800 the station you know what's he doing and 74 00:02:53,350 --> 00:02:50,640 see you have a device right yeah 75 00:02:55,030 --> 00:02:53,360 actually that is it's it's the same it's 76 00:02:57,910 --> 00:02:55,040 not exactly the same but it's the same 77 00:03:01,430 --> 00:02:57,920 measurement device and here you see this 78 00:03:04,070 --> 00:03:01,440 is the kind of sensor we are using for 79 00:03:07,509 --> 00:03:04,080 the measuring of the core temperature 80 00:03:10,149 --> 00:03:07,519 and usually you have to go with several 81 00:03:12,149 --> 00:03:10,159 probes into the rectum into the ear and 82 00:03:13,350 --> 00:03:12,159 so and that's not visible for them 83 00:03:15,430 --> 00:03:13,360 that's a little uncomfortable for you 84 00:03:18,070 --> 00:03:15,440 yeah that's very at least at least it's 85 00:03:20,390 --> 00:03:18,080 uncomfortable and but this is a new type 86 00:03:21,830 --> 00:03:20,400 of sensor it's actually not measuring 87 00:03:25,350 --> 00:03:21,840 the temperature 88 00:03:27,589 --> 00:03:25,360 but it is measuring the heat flux from 89 00:03:31,190 --> 00:03:27,599 for example he's placing that on your on 90 00:03:34,630 --> 00:03:31,200 your front and there's it fixed for 36 91 00:03:35,830 --> 00:03:34,640 hours and here inside you have two 92 00:03:37,830 --> 00:03:35,840 sensors 93 00:03:40,550 --> 00:03:37,840 and one sensor is measuring the heat 94 00:03:43,030 --> 00:03:40,560 coming from your front going to the 95 00:03:45,270 --> 00:03:43,040 first sensor and then going to a certain 96 00:03:48,470 --> 00:03:45,280 material and then coming to the next 97 00:03:50,789 --> 00:03:48,480 sensor and this heat flux 98 00:03:52,710 --> 00:03:50,799 represents in some way 99 00:03:53,910 --> 00:03:52,720 uh your body core temperature especially 100 00:03:56,229 --> 00:03:53,920 under kind of an indirect way of 101 00:03:57,110 --> 00:03:56,239 measuring right okay it's an indirect 102 00:04:00,390 --> 00:03:57,120 way 103 00:04:03,190 --> 00:04:00,400 which is um has to be transformed by 104 00:04:05,509 --> 00:04:03,200 certain algorithms to 105 00:04:07,830 --> 00:04:05,519 yeah to to get the core temperature 106 00:04:09,350 --> 00:04:07,840 profile that's all that's what we need 107 00:04:12,470 --> 00:04:09,360 all right and that's later on that is 108 00:04:13,910 --> 00:04:12,480 stored then on these devices and we get 109 00:04:15,990 --> 00:04:13,920 the data down 110 00:04:18,629 --> 00:04:16,000 several weeks later and we do these 111 00:04:20,710 --> 00:04:18,639 measurements not only on one time but in 112 00:04:23,430 --> 00:04:20,720 the in the early beginning 113 00:04:25,270 --> 00:04:23,440 and then every month at least so that we 114 00:04:26,790 --> 00:04:25,280 can see whether there is a change in 115 00:04:29,510 --> 00:04:26,800 this 116 00:04:31,510 --> 00:04:29,520 curve of the core temperature and we 117 00:04:34,710 --> 00:04:31,520 expect that 118 00:04:36,550 --> 00:04:34,720 the amplitude so to say how how uh the 119 00:04:39,110 --> 00:04:36,560 the delta between 120 00:04:42,390 --> 00:04:39,120 normally that is reduced 121 00:04:43,990 --> 00:04:42,400 due to certain facts okay well so what 122 00:04:46,390 --> 00:04:44,000 what are you guys really hoping to you 123 00:04:50,310 --> 00:04:46,400 know find out and almost 124 00:04:52,390 --> 00:04:50,320 solve so okay that's the the the the uh 125 00:04:54,790 --> 00:04:52,400 one of them is the main points we would 126 00:04:56,390 --> 00:04:54,800 like to look at 127 00:04:58,710 --> 00:04:56,400 when in the mission 128 00:05:01,590 --> 00:04:58,720 we have certain rhythms and whether you 129 00:05:05,510 --> 00:05:01,600 have the same rhythm as i have so it's 130 00:05:06,790 --> 00:05:05,520 not clear who is more disturbed by this 131 00:05:09,029 --> 00:05:06,800 kind of 132 00:05:11,670 --> 00:05:09,039 circadian rhythmic changes and the other 133 00:05:13,909 --> 00:05:11,680 so this gives you an example and gives 134 00:05:16,230 --> 00:05:13,919 you some hints about the 135 00:05:17,270 --> 00:05:16,240 capabilities of the different subjects 136 00:05:19,830 --> 00:05:17,280 and 137 00:05:21,909 --> 00:05:19,840 at least it it's important for our 138 00:05:25,430 --> 00:05:21,919 opinion for long to really long term 139 00:05:27,350 --> 00:05:25,440 space flights and we have to look at at 140 00:05:30,310 --> 00:05:27,360 methods and that 141 00:05:32,070 --> 00:05:30,320 technologies probably to keep 142 00:05:35,430 --> 00:05:32,080 that rhythm and that can be that can be 143 00:05:38,070 --> 00:05:35,440 done by by special lights or by by very 144 00:05:40,150 --> 00:05:38,080 structured meals or so very structured 145 00:05:42,390 --> 00:05:40,160 day then you have can have some inputs 146 00:05:43,990 --> 00:05:42,400 and uh we are working on that but that 147 00:05:46,390 --> 00:05:44,000 is that is so to say the terrestrial 148 00:05:49,270 --> 00:05:46,400 part there's also it is a 149 00:05:50,469 --> 00:05:49,280 space part we have so also a terrestrial 150 00:05:54,390 --> 00:05:50,479 because 151 00:05:55,990 --> 00:05:54,400 this this is now just in the last year 152 00:05:57,749 --> 00:05:56,000 we had several measurements in the 153 00:05:59,110 --> 00:05:57,759 german heart center for heart 154 00:06:01,189 --> 00:05:59,120 transplantation 155 00:06:03,990 --> 00:06:01,199 because these people they have not a 156 00:06:07,430 --> 00:06:04,000 high temperature they get very low their 157 00:06:09,110 --> 00:06:07,440 body temperature at 16 or 15 degrees so 158 00:06:11,590 --> 00:06:09,120 they are very very low to keep they are 159 00:06:15,029 --> 00:06:11,600 waiting for the heart and this device 160 00:06:16,629 --> 00:06:15,039 can be placed outside the the thorax 161 00:06:19,029 --> 00:06:16,639 and to to protocol their core 162 00:06:23,350 --> 00:06:19,039 temperature so very non-invasive very 163 00:06:25,590 --> 00:06:23,360 non-invasive it's easy to clean yeah and 164 00:06:29,830 --> 00:06:25,600 i think in in future you will hear much 165 00:06:32,150 --> 00:06:29,840 more about heat flux sensors in clinics 166 00:06:34,950 --> 00:06:32,160 for monitoring for example not only at 167 00:06:38,710 --> 00:06:34,960 big operations like like 168 00:06:41,110 --> 00:06:38,720 heart transfer but any kind of narcosis 169 00:06:43,189 --> 00:06:41,120 will shut down your possibilities to 170 00:06:44,870 --> 00:06:43,199 regulate your temperature yeah and so 171 00:06:47,749 --> 00:06:44,880 you probably after 172 00:06:49,830 --> 00:06:47,759 certainly you get hypothermic because 173 00:06:52,550 --> 00:06:49,840 the body do not react and this can be 174 00:06:55,110 --> 00:06:52,560 protocoled by this temperature and so 175 00:06:58,230 --> 00:06:55,120 there's a direct clinical application of 176 00:06:59,749 --> 00:06:58,240 this uh method which we designed for 177 00:07:01,830 --> 00:06:59,759 space so 178 00:07:03,270 --> 00:07:01,840 i mean that that really is an amazing 179 00:07:04,390 --> 00:07:03,280 you know earth example of just 180 00:07:06,309 --> 00:07:04,400 technology 181 00:07:07,749 --> 00:07:06,319 developed to find out why astronauts 182 00:07:09,510 --> 00:07:07,759 can't sleep and now it could do 183 00:07:11,430 --> 00:07:09,520 something i mean it's amazing how it can 184 00:07:13,430 --> 00:07:11,440 transfer we are very very 185 00:07:16,309 --> 00:07:13,440 we are very happy that this could be 186 00:07:18,710 --> 00:07:16,319 transferred to it and uh 187 00:07:20,629 --> 00:07:18,720 yeah looking forward about the results 188 00:07:22,390 --> 00:07:20,639 all right well again dr hans christian 189 00:07:24,710 --> 00:07:22,400 gungo one of the principal investigators 190 00:07:26,070 --> 00:07:24,720 for the circadian rhythm study uh thanks 191 00:07:28,070 --> 00:07:26,080 for you know coming on and telling us 192 00:07:29,350 --> 00:07:28,080 about it it's fascinating i i mean i 193 00:07:31,749 --> 00:07:29,360 hadn't even thought about temperature 194 00:07:33,189 --> 00:07:31,759 being used to you know regulate sleep 195 00:07:35,029 --> 00:07:33,199 cycles things like that i just learned 196 00:07:37,110 --> 00:07:35,039 something pretty amazing today so i